The port of Pythagoreio plays a key role in the ferry network of Greece, offering a convenient, scenic, and often essential way to connect with nearby islands. With 24 ferry routes operated by 2 ferry companies, Pythagorio serves as a busy hub for both passenger and freight travel.

Ferries depart regularly from Pythagoreio, with schedules varying seasonally depending on demand, weather conditions, and tourism activity.

Popular routes from this port include Kos - Pythagorio, Patmos - Pythagorio, Kalymnos - Pythagorio connecting Pythagorio with key coastal and island destinations. Depending on the route, crossings can range from quick local hops to longer overnight journeys, often with a choice between high-speed ferries and traditional vessels.

Operators such as Dodekanisos Seaways, Blue Star Ferries run regular services from Pythagoreio, offering a range of onboard amenities including comfortable seating, food and drink options, cabins, and vehicle transport. Ticket options vary by company and vessel type, with choices to suit solo travellers, families, and business passengers alike.

Whether you're island hopping, heading home, or starting a new adventure, Pythagorio offers a reliable and enjoyable gateway to the sea.