Ferries from Chios to Mytilini can peak at up to 2 daily sailings, Sailing frequency typically peaks in the summer months, with approximately 7 departures offered each week. While schedules may be reduced from Chios to Mytilini in other seasons, ferry services are often still available.

Ferry travel from Chios to Mytilini on average typically takes 2h 60m. The earliest ferry usually leaves from Chios at 04:20, arriving to Mytilini at 07:00 The latest ferry departs at 21:45 and arrives at 11:15.