Ferries from Mastihari to Kalymnos can peak at up to 4 daily sailings, Sailing frequency typically peaks in the summer months, with approximately 9 departures offered each week. While schedules may be reduced from Mastihari to Kalymnos in other seasons, ferry services are often still available.

Ferry travel from Mastihari to Kalymnos on average typically takes 45m. The earliest ferry usually leaves from Mastihari at 09:00, arriving to Kalymnos at 09:45 The latest ferry departs at 22:31 and arrives at 23:01.