Ferries from Mytilini to Chios can peak at up to 2 daily sailings, Sailing frequency typically peaks in the summer months, with approximately 7 departures offered each week. While schedules may be reduced from Mytilini to Chios in other seasons, ferry services are often still available.

Ferry travel from Mytilini to Chios on average typically takes 2h 60m. The earliest ferry usually leaves from Mytilini at 06:10, arriving to Chios at 08:30 The latest ferry departs at 19:00 and arrives at 22:00.