Ferries from Mytilini to Piraeus can peak at up to 2 daily sailings, Sailing frequency typically peaks in the summer months, with approximately 7 departures offered each week. While schedules may be reduced from Mytilini to Piraeus in other seasons, ferry services are often still available.

Ferry travel from Mytilini to Piraeus on average typically takes 12h 50m. The earliest ferry usually leaves from Mytilini at 06:10, arriving to Piraeus at 00:50 The latest ferry departs at 19:00 and arrives at 08:10.