Ferries from Piraeus to Donousa can peak at up to 4 daily sailings, Sailing frequency typically peaks in the summer months, with approximately 7 departures offered each week. While schedules may be reduced from Piraeus to Donousa in other seasons, ferry services are often still available.

Ferry travel from Piraeus to Donousa on average typically takes 13h 30m. The earliest ferry usually leaves from Piraeus at 07:00, arriving to Donousa at 01:00 The latest ferry departs at 17:30 and arrives at 18:25.