Ferries from Piraeus to Mytilini can peak at up to 2 daily sailings, Sailing frequency typically peaks in the summer months, with approximately 7 departures offered each week. While schedules may be reduced from Piraeus to Mytilini in other seasons, ferry services are often still available.

Ferry travel from Piraeus to Mytilini on average typically takes 12h 50m. The earliest ferry usually leaves from Piraeus at 07:00, arriving to Mytilini at 07:00 The latest ferry departs at 23:59 and arrives at 11:15.