Ferries from Rhodes to Santorini can peak at up to 5 daily sailings, Sailing frequency typically peaks in the summer months, with approximately 8 departures offered each week. While schedules may be reduced from Rhodes to Santorini in other seasons, ferry services are often still available.

Ferry travel from Rhodes to Santorini on average typically takes 18h 10m. The earliest ferry usually leaves from Rhodes at 07:00, arriving to Santorini at 02:40 The latest ferry departs at 17:01 and arrives at 21:10.