Ferries from Genoa to Palermo can peak at up to 1 daily sailings, Sailing frequency typically peaks in the summer months, with approximately 7 departures offered each week. While schedules may be reduced from Genoa to Palermo in other seasons, ferry services are often still available.

Ferry travel from Genoa to Palermo on average typically takes 20h 40m. The earliest ferry usually leaves from Genoa at 18:00, arriving to Palermo at 17:00 The latest ferry departs at 23:59 and arrives at 21:45.