Ferries from Kalymnos to Piraeus can peak at up to 3 daily sailings, Sailing frequency typically peaks in the summer months, with approximately 9 departures offered each week. While schedules may be reduced from Kalymnos to Piraeus in other seasons, ferry services are often still available.

Ferry travel from Kalymnos to Piraeus on average typically takes 16h 60m. The earliest ferry usually leaves from Kalymnos at 07:00, arriving to Piraeus at 06:05 The latest ferry departs at 23:40 and arrives at 21:05.