Ferries from Leros to Piraeus can peak at up to 2 daily sailings, Sailing frequency typically peaks in the summer months, with approximately 8 departures offered each week. While schedules may be reduced from Leros to Piraeus in other seasons, ferry services are often still available.

Ferry travel from Leros to Piraeus on average typically takes 15h 25m. The earliest ferry usually leaves from Leros at 10:30, arriving to Piraeus at 08:15 The latest ferry departs at 23:00 and arrives at 21:15.