Ferries from Piraeus to Kalymnos can peak at up to 2 daily sailings, Sailing frequency typically peaks in the summer months, with approximately 7 departures offered each week. While schedules may be reduced from Piraeus to Kalymnos in other seasons, ferry services are often still available.

Ferry travel from Piraeus to Kalymnos on average typically takes 15h 40m. The earliest ferry usually leaves from Piraeus at 07:00, arriving to Kalymnos at 01:20 The latest ferry departs at 23:55 and arrives at 22:45.