Ferries from Piraeus to Leros can peak at up to 3 daily sailings, Sailing frequency typically peaks in the summer months, with approximately 9 departures offered each week. While schedules may be reduced from Piraeus to Leros in other seasons, ferry services are often still available.

Ferry travel from Piraeus to Leros on average typically takes 15h 25m. The earliest ferry usually leaves from Piraeus at 07:00, arriving to Leros at 00:10 The latest ferry departs at 23:55 and arrives at 22:30.